The data presented in this paper suggest that some patients who meet borderline criteria and have atypical depression The aim of this study was to compare imipramine (Tofranil) and phenelzine (Nardil), both of which had been found by personal experience to be of value in the treatment of depressive states
[4] [5] Nevertheless, in cases of treatment-resistant unipolar depression, a double-blind crossover study of imipramine and phenelzine found that response to treatment occurred more frequently in patients
F
Response to phenelzine and imipramine in placebo nonresponders with atypical depression
Monoamine-oxidase inhibitors are used much less frequently than tricyclic and related antidepressants, or SSRIs and related antidepressants because of the
The aim of this study was to compare imipramine (Tofranil) and phenelzine (Nardil), both of which had been found by personal experience to be of value in the treatment of depressive states
Phenelzine is used to treat certain types of depression
66 – 68 The study of Stewart et al 69 in patients with major depression showed a robust therapeutic effect of imipramine in patients without, but not with Imipramine comes as a tablet and a capsule to take by mouth
Since their response to phenelzine appears to be unique, this suggests that atypical depression may be a distinct subgroup of unipolar depressive illness
These patients were found to benefit selectively from therapy with monoamine Imipramine typically increased and phenelzine decreased GR expression in other feedback-related brain regions such as the paraventricular hypothalamus and prefrontal cortex
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They're effective, but they've generally been replaced by antidepressants that cause fewer side effects
Phenelzine sulphate should not be administered at the same time as, or within 14 days of, treatment with other MAOIs, buspirone, or dibenzazepine derivative drugs (including tricyclic antidepressant agents, perphenazine or carbamazepine)
Although both medications were shown effective in comparison with placebo, the improvement was more pronounced with phenelzine than imipramine or placebo
Double-blind study of imipramine versus phenelzine in melancholias and dysthymic disorders
A double-blind crossover trial of imipramine and phenelzine for outpatients with treatment-refractory depression