The use of sedating antihistamines should be avoided, especially because their sedative effects may mask a deterioration in consciousness, caused by the
with more marked sedating activ-ity are traditionally used to pro-mote sleep and are available in over-the-counter medicines such as Night Nurse (promethazine) and Nytol
First-generation oral antihistamines, including diphenhydramine (Benadryl) and chlorpheniramine (Chlor-Trimeton), easily cross the blood-brain barrier and affect H1
How it works Phenergan is a brand (trade) name for promethazine which may be used to treat various conditions such as allergies, rhinitis, nausea or vomiting, or
43% of reviewers reported a positive effect, while 41% reported a negative
chlorpheniramine (Chlor-Trimeton), diphenhydramine (Benadryl), hydroxyzine (Vistaril), promethazine (Phenergan, Promacot) loratadine (Claritin, Alavert), desloratadine
promethazine decreases effects of epinephrine by pharmacodynamic antagonism
68-70 Serotonin antagonists are typically thought to be non-sedating, however a randomised trial reported that ondansetron may be as sedating as metoclopramide, but less than promethazine
H 1 receptors are present in the bronchial tubes and in circulatory system
5 mg/5ml oral suspension or 25-37 lbs: 5 ml of 12
a skin rash
I have a patient right now who is literally faking allergies in order to get IV Benadryl to potentiate the opioids he’s being given
Side effects such as confusion and severe drowsiness may be more likely in older adults
2 Doxylamine but little experience said to be given more for sleeping than phenergan which is used more as an AH so idk 3
promethazine 10mg nocte reduced to promethazine 5mg) if weaning, time frame (e
on itch) Typical adult doses for sedation are 25 mg to 50 mg
However, the concentrations required for this effect are much higher than therapeutic dozes can make
Common examples include diphenhydramine (brand name Unisom Sleep Gels), doxylamine (brand name Restavit) and promethazine (branded Phenergan Benadryl is readily available and fast-acting, can have a calming effect, and can even help you sleep, so it may help you deal with feelings of anxiety
For example, diphenhydramine 1-2 mg/kg (maximum 50 mg) can be given PO, IM, or IV and followed by a maintenance dose for 2-3 days
But promethazine is more sedating for me, hydroxyzine has better anxiolysis
Applies to: Benadryl (diphenhydramine) and Phenergan (promethazine) Using diphenhydrAMINE together with promethazine may increase side effects such as drowsiness, blurred vision, dry mouth, heat intolerance, flushing, decreased sweating, difficulty urinating, abdominal cramping, constipation
But if stomach upset occurs; administer it with meals