These are summarized in Table 1
Preferred collection container: Stat/Line draws: 3 mL green/yellow-top (plasma separator) tube Routine requests/off-site specimens: 3
Do not use a gel-barrier tube
0 mg/L Alternative Name (s) Hydantoin,Dilantin® LOINC® Codes, Performing Laboratory Service Area must be determined Preferred Specimen (s) 1 mL serum
Reference Range
Mar 13, 2020 Last Updated December 20th, 2021 What is Phenytoin? Phenytoin is a drug that is used to control seizures and it is generally used as an anticonvulsant or antiepileptic drug
Free Phenytoin
Toxic effects such as
Red-top tube, lavender-top (EDTA) tube or green-top (sodium heparin or lithium heparin) tube
Plasma – transfer to plastic vial and label with patient’s name and “heparin plasma”
The total phenytoin reference range varies by age, as follows: Children and adults: 10-20 µg/mL [ 4] Neonates: 8-15 µg/mL
In patients with renal failure associated Hepatic* ALP, AST, ALT, Bili Tot, Bili Dir, Bili Indir, Protein, Albumin
3968-5
Ninety percent of nontoxic patients have levels ≤2
1
Your healthcare provider will figure out the best dose and blood level for you based in part on how well your seizures are controlled and how you feel
PT, PTT, TPT, Protein S, Protein C, Lupus Anti-Coagulant Serum chemistry tests: Digoxin, Dilantin, Drug Levels, Homocystine, Lithium Phenytoin (Dilantin) Blood Test
1 - 6
3 mean) in patients on other anticonvulsants (phenytoin, carbamazepine) and lower than normal among patients Vacutainer Guide
Lamotrigine is 55% bound to plasma proteins and is metabolized predominantly to an inactive 2-N-glucuronide conjugate
The longer half-lives are observed in patients on concomitant valproic acid therapy
Serum or plasma should be separated from contact with the cells within 2 hours of collection
The tubes are clear in color
1-3 Biotin functions as a cofactor for five mammalian enzymes that catalyze specific carboxylation reactions
3969-3
Decreased phenytoin levels may indicate that more phenytoin is necessary to achieve a
Phenytoin, Free - Phenytoin is used singly or in combination with other anticonvulsants to treat grand mal epilepsy
This knowledge ensures accurate test results, improves patient care, and enhances overall outcomes
Dilantin; Diphenylhydantoin; Epanutin; DIL; DILANTIN LEVEL; Laboratory
STAT requests for this test will be performed on a STAT basis (supervisory staff approval is not required)
Monitoring for appropriate therapeutic concentration of both free and total phenytoin: free phenytoin level is the best indicator of adequate therapy in renal failure
This will not be achieved for at least 7 days after starting therapy or changing dose
Minimum Vol : 0
Free Phenytoin requires 6 mL blood; if ordered, both the free and total will be performed at Harborview with a turn-around time of 1 - 3 days