Indicated for prophylaxis of common migraine headache
For high blood pressure (hypertension): For oral dosage form (extended-release capsules): Adults—At first, 80 milligrams (mg) once a day, given at bedtime
A Cochrane review of 26 studies of propranolol 36 at any dose versus placebo for migraine prophylaxis involved 668 patients
Thyrotoxic crisis By intravenous injection Adult 1 mg, to be given over 1 minute, dose may be repeated if necessary at intervals of 2 minutes, maximum total dose is 5 mg in anaesthesia; maximum 10 mg per course
Migraine with or without aura (2) topiramate or propranol are the suggested first line prophylactic agents Prescribe propranolol with caution in people with: Diabetes — may alter blood glucose levels and response to hypoglycaemia
Zolmitriptan 2
Daily dose range (the most effective dose or dose range is shown in parentheses) Propranolol hydrochloride (should be specifically considered as first-line agent) *: 40 to 320 mg (80-240 mg) Timolol maleate (should be specifically considered as first-line agent) *: 20 to 30 mg
The clinical features and management of chronic migraine (defined as ≥15 headache days per month) are discussed separately
It is characterized by severe periodic episodes of headache often accompanied by nausea, vomiting, photophobia, and phonophobia and is relieved with sleep
doi Indications and dose For propranolol hydrochloride Hyperthyroidism with autonomic symptoms for propranolol hydrochloride By mouth
Zolmitriptan [unlicensed indication] or naratriptan [unlicensed indication] are suitable alternatives to frovatriptan
Prevention 020 7829 8608 (Monday to Friday
5
In a double-blind, cross-over multicentre trial, the prophylactic antimigraine effect of the beta 1-selective beta-blocker metoprolol was evaluated and compared with that of the non-selective beta-blocker propranolol
i
The main adverse effects of Migraine
Objective: To assess the efficacy and safety of low-dose topiramate in migraine prophylaxis vs propranolol
Moreover, a phase-IV double-blind equivalence trial completed by 666 patients and designed to assess the efficacy and tolerability of two doses of flunarizine (5 mg and 10 mg o
The potential central action of β-adrenergic blockers occurs by way of inhibiton of central β-receptors which interact with adrenergic pathways increasing vigilance, interaction with 5-HT receptors and cross-modulation of serotonergic system ( 20 , 21 )
Although many trials have relevant methodological shortcomings, there is clear evidence that propranolol is more effective than placebo in the short-term interval treatment of migraine
Propranolol, timolol, methysergide, valproic acid, and topiramate (Topamax) have been approved by the FDA for migraine prophylaxis
e) Topiramate 25mg at night for a week then titrated up is a licensed alternative for those who cannot tolerate or are contraindicated for propranolol
The most common side-effects are feeling tired, cold hands and feet, disturbed sleep, and stomach upset
At a dosage of 50 mg twice per day, topiramate reduced migraine frequency by Propranolol is also used to treat tremors of certain causes, and to prevent migraine headaches
[1] This figure includes factors such as medical costs and loss of productivity (i
While millions of Americans suffer from migraine headaches, roughly 3%-13% of identified migraine patients are on preventive therapy, while an estimated 38% actually need a preventive agent
Propranolol tablets 40 mg 3 times a day costs £9
If prophylaxis is necessary, propranolol is the drug of choice during pregnancy and lactation
flunarizine is considered a drug of first choice in migraine prophylaxis
It may take up to 12 weeks at an adequate dose for therapeutic benefits to
Although the usual recommended dose of propranolol is 40 mg bd, 10 mg tds may be sufficient for migraine prophylaxis
Medications used to treat this condition can be divided into two broad categories: symptomatic or acute-care medications to treat individual migraine episodes, and prophylactic or preventive
Although propranolol is still the drug of first choice for migraine prophylaxis, the optimal antimigraine dose of this drug is still unknown
1 mg, to be given over 1
Propranolol
Eidlitz-Markus et al
Tips and traps in diagnosis
Neonate Initially 250–500 micrograms/kg every 6–8 hours, adjusted according to response
Daily dose range (the most effective dose or dose range is shown in parentheses) Propranolol hydrochloride (should be specifically considered as first-line agent) *: 40 to 320 mg (80-240 mg) Timolol maleate (should be specifically considered as first-line agent) *: 20 to 30 mg
Propranolol, which treats high blood pressure, irregular heart rhythms, chest pain, and other heart symptoms, is also approved by the US Food and Drug Administration (FDA) for preventing migraine attacks
In this study, 60 patients were enrolled (30 in the difficulty concentrating
Beta-blockers are Migraines are common, with a prevalence of 1% to 3% in children three to seven years of age, 4% to 11% in children seven to 11 years of age, and 8% to 23% in those 15 years of age
35, p < 0
For consumers: dosage, interactions, side effects
Metoprolol was used in a dosage of 50 mg b
61–2
Propranolol is effective in migraine prevention at a daily dose of 80–240 mg (Barbanti et al
Migraine
Objective: To assess the efficacy and safety of low-dose topiramate in migraine prophylaxis vs propranolol
Both drugs had significant efficacy with regard to frequency, intensity, and duration of migraine episodes
There is a wide array of options for migraine prophylaxis; many of the available drugs are clearly proven to be effective and yet are underused in Australia
The dosage may be increased gradually to achieve optimal migraine prophylaxis
Propranolol seems to be as effective and safe as a variety of other drug
d) Propranolol 80 – 240mg daily in divided doses should be offered first line as prophylactic therapy for migraine1, 2