The fact that dexamethasone did not significantly increase the mRNA levels of the surfactant proteins or ABCA3 while a similar total steroid dose of Beta-PO 4 +
In mammals, glucocorticoids and autonomic neurotransmitters contribute to the maturation of the surfactant system
Conclusion: Our data support
We conclude that glucocorticoids have a significant effect to increase lung surfactant lipid pools of adult rat lungs by changing the phospholipid content of lamellar bodies, without
The results indicate that mechanisms other than increased synthesis of SP-A are involved in hyperoxia-inducedSP-A accumulation and that
53% of births
Reduced placental and birth weight have been recorded in animals and humans after long term treatment
The results indicate that mechanisms other than increased synthesis of SP-A are involved in hyperoxia-inducedSP-A accumulation and that dexamethasone does not affect the abnormal accumulation of pulmonary surfactant induced byhyperoxia
0) were treated with intravenous dexamethasone (DEX): 0
calf-lung surfactant extract and dexamethasone, 0 of 24; p less than 0
The infants in the 42-day dexamethasone group received dexamethasone sodium phosphate (Elkins-Sinn, Richmond, Va
Impact: Antenatal administration of dexamethasone can function in concert with intestinal surfactant protein-D to decrease systemic inflammatory responses, and protect intestinal barrier integrity in a neonatal rat model of NEC
02), compared to those Surfactant replacement was established as an effective and safe therapy for immaturity-related surfactant deficiency by the early 1990s
Design: Prospective, randomized, controlled study
[2,3] Dexamethasone and betamethasone cause to produce surfactant in fetus lung and thereby it reduces the resistant between layers of airways and sacs to simply slide on each other and eventually easily breathing of neonate after birth A surfactant and a residual fraction was isolated from the cultures by discontinuous sucrose gradi
In addition to binding to specific nuclear steroid receptors, dexamethasone also interferes with NF-kB activation and apoptotic pathways
Dexamethasone did not inhibit basal or stimulated IL-8 release from macrophages from patients with COPD but inhibited release in smokers
In this study, the effects of insulin and dexamethasone on the expression and mRNA transcription of 4 pulmonary surfactant-associated proteins [surfactant protein (SFTP)A, SFTPB, SFTPC and SFTPD] were examined
Impact of antenatal dexamethasone administration on respiratory distress syndrome in surfactant treated infants
A placebo-controlled, randomized, double-blind study was performed to determine whether prenatal dexamethasone (DEX) treatment improves the outcome of the preterm infant when exogenous surfactant is available